2. Signaling Pathways
  3. GPCR/G Protein
  4. P2Y Receptor
  5. P2Y6 Receptor Isoform
  6. P2Y6 Receptor Antagonist

P2Y6 Receptor Antagonist

P2Y6 Receptor Antagonists (3):

Cat. No. Product Name Effect Purity
  • HY-13104
    MRS 2578
    		Antagonist 98.15%
    MRS 2578 is a selective and potent P2Y6 receptor antagonist with IC50s of 37 nM (human) and 98 nM (rat). MRS 2578 exhibits insignificant activity at P2Y1, P2Y2, P2Y4, and P2Y11 receptors.
  • HY-161727
    P2Y14R antagonist 1
    		Antagonist
    P2Y14R antagonist 1 (compound I-17) is a selective P2Y14R antagonist with an IC50 of 0.6 nM. It exhibits potent P2Y14R antagonistic activity, both in vitro and in vivo efficacy, and favorable pharmacokinetic profiles. P2Y14R antagonist 1 reduces the release of inflammatory factors and cell pyroptosis through the NOD-like receptor family pyrin domain-containing 3 (NLRP3)/gasdermin D (GSDMD) signaling pathway. P2Y14R antagonist 1 holds promise for research in the field of acute gouty arthritis.
  • HY-168098
    P2Y6R antagonist 1
    		Antagonist
    P2Y6R antagonist 1 (compound 5ab) is a selective, orally active P2Y6R antagonist with an IC50 value of 19.6 nM. P2Y6R antagonist 1 has anti-inflammatory activity.